Through a very strong bioinformatics capability in Arkansas, resources from across the state have been assembled to conduct a co-clinical trial on treating lung cancer using a precision medicine approach with a blood biopsy to detect circulating tumor DNA. The results are important in providing FDA with information needed to respond to clinical trial data, assess liquid (plasma) biopsies, and understand more about treatment modalities for lung cancer. Arkansas has taken an early leadership position in the scientific and methodological advancements in liquid biopsies to further the development of lung cancer-based precision medicine.